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Dr. Ángel Alfonso Zarain-Herzberg


E-mail:


+52 (55) 56232258




MD, PhD
Full Time Professor
National Researcher Level II
PRIDE C  




Research Lines

Molecular Biology of Cardiac Muscle and Brain

Proyects

  • Cloning and expression of  the 5´-regulatory region of the cardiac calsequestrin gene
  • Transcripcional Regulation of the grin1 gene during neuronal differenetiation and in cardiac muscle
  • Transcripcional Regulation of the SERCA2 gene in the heart by metabolically active compounds

Recent Book Chapters

  1. Zarain-Herzberg, A., and Alvarez-Fernandez, G. The human SERCA2 gene: genomic organization and promoter characterization. En: Signal Transduction and Cardiac hypertrophy (Dhalla, N.S., Hryshko, L, Kardami, E., Singal, P.K.) Kluwer Acad. Pu. (Boston, USA) 2003, ISBN 1-4020-7218-X, pp 479-496.
  2. Rupp, H, Zarain-Herzberg, A. and Maisch, B. Drug Development Based on Functional Genomics of Overloaded Cardiomyocytes. En: Frontiers in Cardiovascular Health (Dhalla, N.S., Chockalingam, A., Berkowitz, H.J. Singal, P.K. Ed.) Kluwer Acad. Pu. (Boston, USA) 2003, ISBN 0-7923-8147-5, pp 1 77-194.
  3. Zarain-Herzberg, A. (2004) Diagnóstico Molecular de Enfermedades Cardiovasculares. En: Diagnóstico Molecular en Medicina (Jaime Mas-Oliva, Ed.) 1a. edición. Editorial Manual Moderno, S.A de C.V., México, D.F. ISBN 968-426-999-4, pp 127-147.
  4. Zarain-Herzberg, A. (2006) Expresión de la Bomba de Calcio del Retículo Sarcoplásmico en el Corazón. En: Tratado Cardiología (Jesús Vargas Barrón, Ed.) Editorial Intersistemas, S.A. de C.V., México, D.F., ISBN 970-655-860-8, pp 125-130.
  5. Zarain-Herzberg, A. (2007) Diagnóstico de enfermedades genéticas cardiovasculares y distrofias musculares. En: Diagnóstico Molecular en Medicina, 2a. edición. (Jaime Mas-Oliva, Ed.) Editorial Manual Moderno, S.A de C.V., México, D.F.
  6. Zarain Herzberg, A. (2007) Regulación de la Expresión de los Genes. En: Bioquímica. (Díaz Zagoya, Juárez Oropeza, M. Eds.) Editorial McGraw-Hill Interamericana, México.

Recent Publications in Journals

  1. Zarain-Herzberg, A., and Rupp, H. (2002) Therapeutic potential of CPT-1 inhibitors: cardiac gene transcription as a target. Expert Opinion Investig Drugs 11(3):345-356.
  2. Zarain-Herzberg, A., y Alvarez-Fernandez, G. (2002) Sarco(endo)plasmic Reticulum Ca2+-ATPase Gene: Structure and Transcriptional Regulation of the Human Gene. The Scientific World Journal 2, 1469-1483.
  3. Rupp, H., Zarain-Herzberg, A.,y Maisch B. (2002) The use of partial fatty acid oxidation inhibitors for metabolic therapy of angina pectoris and heart failure. Herz 27(7):621-636.
  4. Delgado-Coello, B., Santiago-García, J., Zarain-Herzberg, A. and Mas-Oliva, J. (2003) Plasma membrane Ca2+-ATPase mRNA expression in murine hepatocarcinoma and regenerating liver cells. Molec. and Cell Biochem. 247(1-2):177-184.
  5. Lee-Rivera, I, Zarain-Herzberg, A., and López-Colomé, A.M. (2003) Developmental Expression of N-Methyl-D-Aspartate Glutamate Receptor 1 Splice Variants in the Chick Retina. J. of Neuroscience Res. 73(3):369-383.
  6. Zarain-Herzberg, A, Juárez-Rubí, R., Álvarez-Fernández G. and Medina A.B. (2004) Transcriptional Regulation of the Human Sarcoplasmic Reticulum Ca2+-ATPase and Calsequestrin Genes in Cardiac Myocytes. Journal of Muscle Research and Cell Motility. 25 (8): 609-610.
  7. Zarain-Herzberg, A., Lee-Rivera, I, Rodriguez, G. and López-Colomé, A.M. (2005) Cloning and characterization of the chick NMDA receptor subunit-1 gene. Molecular Brain Research. 137 (1-2) 235-251.
  8. Zarain-Herzberg, A. (2006) Regulation of the sarcoplasmic reticulum Ca2+-ATPase expression in the hypertrophic and failing heart. Canadian Journal of Physiology and Pharmacology. (84) 509-521.
  9. Moreno-González, G. y Zarain-Herzberg, A. (2006) Papel de los receptores de glutamato en la diferenciación neuronal. Salud Mental. 29: 38-48.
  10. Reyes-Juárez, J.L. y Zarain-Herzberg, A. (2006) El retículo sarcoplásmico, su función y su papel en las enfermedades cardiacas. Archivos de Cardiología de México. 76: 18-32.

Collaborators

  • Téc. Asoc. C: Biol. Gabriela Rodríguez Rodríguez
  • Dr. Heinz Rupp, Univ. of Marburg, Germany

Students

Undergraduate:

  • Julián Guzmán Bárcenas

Graduate:

  • Gabriel Moreno González
  • José Luis Reyes Juárez

Memberships

  • Member of the Mexican Academy of Sciences
  • Member of the International Academy of Cardiovascular Sciences
  • Member of the Mexican Society of Biochemistry
  • Member of the International Society for Heart Research
  • Member of the American Heart Association
  • Member of the American Society for Biochemistry and Molecular Biology