correo-e: vjhilser@utmb.edu
B.S. in Chemistry, St. John's University,
New York, NY. 1987
M.S. in Biotechnology, Manhattan College, New York, NY. 1991
Ph.D. The Johns Hopkins University, Baltimore, MD. 1995
Post-Doctoral Fellow with Prof. Ernesto Freire,
Department of Biology and Biocalorimetry Center
The Johns Hopkins University, Baltimore, MD. 1995-1997
Assistant Professor - Dept. of Human Biological
Chemistry & Genetics University of Texas
Medical Branch, Galveston, TX. 1997-2002
Associate Professor - Dept. of Human Biological
Chemistry & Genetics University of Texas
Medical Branch, Galveston, TX. 2002-
Áreas de interés:
Conferencia
Insights into the protein ensemble
Resumen
It is now well-known that rather than being discrete
structures, the native states of proteins are more
accurately described as ensembles of conformational
states. In spite of this insight, little is known of
the detailed structure and energetics of these
conformational excursions, nor is it clear what
quantitative role fluctuations play in important functional
processes such as molecular recognition, signal
transduction, and allosterism. I will describe
our laboratory's progress in both theoretically modeling
the ensemble and experimentally characterizing the role
that fluctuations play in mediating biological processes.